Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

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Systemic lupus erythemato sus in patients diagnosed with treatment-resistant acne. We highlight the rarity and early age of occurrence.

They bolhlso affect the torso and supraclavicular region but may also affect the mucosae, particularly in the mouth and pharynx. Bullous systemic lupus erythematosus is a rare subset of systemic lupus erythematosus that is even rarer in pediatric patients. Sapadin AN, Fleischmajer R.

The patient was then started on hydroxycloroquine mg daily with clinical improvement in 45 days Figure 4. The diagnosis of comedonic DLE was confirmed mainly by the histopathological changes. Vesiculobullous systemic lupus erythematosus.

Luups should therefore be tested for this deficiency before being treated with this drug. SLE with blisters is characterized by polycyclic lesions with blisters on the edges.

Lúpus eritematoso sistêmico bolhoso: diagnóstico diferencial com dermatite herpetiforme

Clinical and laboratory abnormalities in this patient confirmed the suspicion of BSLE. J Pak Med Assoc. The dermatologic examination showed lightly-colored violaceous, infiltrated plaques of various sizes and atrophic scars on the right ear, dorsal aspect of the nose and chin.

J J Invest Dermatol. Patients with glucosephosphate dehydrogenase deficiency may present with severe hemolysis when taking dapsone. Histology from skin biopsy revealed subepidermal blister filled with fibrin, lymphomononuclear cells and neutrophils, thickening of the basement membrane in the dermal papillae and mild perivascular lymphoplasmacytic infiltrate in the papillary, superficial dermis Figure 4.

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Direct immunofluorescence lupue fluorescence of the keratinocyte nuclei. BSLE is a rare disease that has an incidence of less than 0. Services on Demand Journal.

Approved by the Advisory Board and accepted for publication on Discoid lupus erythematosus presenting as acneiform pitting scars.

Bullous systemic lupus erythematosus: Direct immunofluorescence reveals a linear or granular deposition of IgG, IgA and C3 in the basement membrane zone. A lu;us female patient was admitted with a complaint of tense vesiculobullous lesions, both isolated and in clusters, on her face, neck, torso and oral and genital mucosae on circinate and erythematous edematous plaques Figures 1234.

Autoimmune blistering skin diseases. The histopathological examination showed acanthosis, vacuolar degeneration of the basal cell layer, pigmentary incontinence, periadnexial mononuclear infiltrate, follicular plugging and comedones. Gluten intolerance was also investigated, and the results were negative for IgA anti-gliadin, IgG anti-gliadin, anti-endomysium and antitissue transglutaminase antibodies. Open in a separate window. Overview of common, rare and atypica manifestations of cutaneous lupus erythematosus and histopathological correlates.

Pruritus may or may not be present. The classic histological features blhoso lupus erythematosus LEsuch as epidermal atrophy and hydropic degeneration of the basal cell layer, are absent in BSLE. Bullous Systemic Lupus Erythematosus.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. Author information Article notes Copyright and Bllhoso information Disclaimer.

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The activity of the bullous disease can occur isolated from or concomitantly with other systemic manifestations of SLE, nephritis and serositis in particular.

The diagnosis of DLE is confirmed by histopathological examination. Colchicine is a therapeutic option for neutrophil-mediated bullous diseases. Histopathological examination of the sample from the cervical lymph node biopsy revealed reactive lymphoid hyperplasia. The patient remained stable during 1 year of follow-up.

Bullous systemic lupus erythematosus in a year-old child

Int J Dermatol ; Am J Emerg Med. Laboratory tests revealed anemia Hb – 8. Paniker U, Levine N. Camisa C, Sharma HM. Find articles by Nelise Ritter Hans-Bittner. Trichoepithelioma of the vulva: Colchicine for epidermolysis bullosa acquisita. The present case reinforces the importance of taking into consideration the various forms of presentation and the atypical behavior of discoid CLE, like the presence of acneiform lesions, accompanied by suggestive signs of CLE, that do not respond to conventional treatment to acne vulgaris.

With discontinuation of the tetracycline there was an acute recurrence of the lesions. Childhood-onset bullous systemic lupus erythematosus. The differential diagnosis of comedogenic discoid CLE are: A biopsy of the skin lesion was carried out, and the pathological findings included a subepidermal blister with neutrophilic microabscesses in the dermal papillae suggestive of dermatitis herpetiformis Figure 4.

Tense bullae overlying an erythematous base on the right axilla.