PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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Linkage of early-onset familial breast cancer to chromosome 17q21.

Am J Hum Genet. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset.

Genetic analysis of breast cancer in the cancer and steroid hormone study. This article has been cited by other articles in PMC. Inheritance of proliferative breast disease in breast cancer kindreds. Familial breast-ovarian cancer locus on chromosome 17qq If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

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Linkage of early-onset familial breast cancer to chromosome 17q Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset early-onsey.

– Document – Linkage of early-onset familial breast cancer to chromosome 17q21

Genetic epidemiology of breast cancer: Genetic epidemiology of breast cancer in Britain. A new statistical test for linkage heterogeneity. This article has been corrected. Please review our privacy policy. Inheritance of human breast cancer: Support Center Support Center.

The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Estimating the power of linkage analysis in hereditary breast cancer. See Am J Hum Genet. Author information Copyright and License information Disclaimer. Segregation and linkage analysis of nine Utah breast cancer pedigrees.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Open in a separate window. Strategies for multilocus linkage analysis in humans. Closing in on a breast cancer gene on chromosome 17q. However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.

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Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease. Associated Data Supplementary Materials.

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