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FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Multiple Sclerosis and Related Disorders.

Experimental and Molecular Pathology. Moreover, the potent disassemblable PNps indicate a wide application for the development of vaccines against other pathogens, and for protein drug delivery and controlled release.

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

Broadband wave plates made by plasmonic metamaterials. Kinetics, mechanisms, and implications for water treatment. The deletion of part of loop B can block the formation of the long helix ABC, fixing the protein structure in the pre-fusion state Journal of Diabetes Research.

Study of a new bone-targeting titanium implant-bone interface. Demento SL, et al. However, the immunomodulatory effects of PNp have been shown to be a function of many aspects, including size 4748shape 4950charge 51surface chemistry 52 and administration route 32 A Combined Computational and Experimental Study.

Reactive Metabolite-induced Protein Glutathionylation: The rescue of reassortant viruses was determined by hemagglutination of chicken red blood cells. Accompanying the isolation and artificial generation of broadly neutralizing antibodies 10 — 16some HA stalk domain-based immunogens have been constructed and proven protective lri some extent in vivo 17 — Journal of Medicinal Chemistry. Adjacent segment degeneration after lumbar spinal fusion compared with motion-preservation procedures: Zhou LBeuerman RW.


Effects of galectin-3 inhibition on endometrial cell cycle and adhesion. – Abstract – Europe PMC

Amino acid differences in HA structures. This result is consistent with previous findings on the M2e-based and HA stalk-based immunity mechanism 1853 — Environmental Science and Pollution Research International. Anionic Lanthanide Metal-Organic Frameworks: The Journal of Physiology.

Effect of D3 dopamine receptor on dopamine D4 receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats and spontaneously hypertensive rats. Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine STF2. In addition, the abiotic nature of PNps also enhances their amenability to cold chain-independent storage for 3 months at room temperature, a desirable property for vaccine transport to low-income countries. In order to investigate the role of gal-3 in the establishment of human endometrial receptivity, the expression of gal-3 in human endometrial cell line RL was silenced by RNA interference technology using gal-3 specific small RNA.

The unbound hrHA molecules and self-crosslinked hrHAs cannot be pelleted by high-speed centrifugation The developed plates were rinsed with purified water and air dried before counting using a BioreaderE Biosys, Germany. Blue light-promoted cross-coupling of aryldiazoacetates and diazocarbonyl compounds. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype.


Patch-clamp fluorometry-based channel counting to determine HCN channel conductance.

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

The S gene is necessary but not sufficient for the virulence of porcine epidemic diarrhea virus novel variant strain BJC. An antibody titer follow-up study shows that PNp-induced antibodies specific to human M2e, PR8, and Aic were durable up to 4 months after the last immunization in mice Fig.

The quest for a universal flu vaccine: Blue arrows indicate the location of flexible linkers. All other authors have no potential conflict of interest. Frontiers in Plant Science. Bioreducible alginate-poly ethylenimine nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses.

Moreover, the Uni4C13 immunization dramatically reduced lung virus titers at day 5 post infection compared to the mock-immunization Fig. A solid-state NMR study. Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy Experimental and Therapeutic Medicine.

There is no universal particulate design principle yet. Journal of Asian Natural Products Research.