Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
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Emerging Roles of JmjC Domain-Containing Proteins.
Eukaryotic Ortholog Groups More Evidence of domain swapping within the jumonji family of transcription factors. National Institutes of Health. Select item s and click on “Add to basket” to create your own collection here entries max. You work at the same institute as any of the authors. F does not claim any ownership in the Material that you or any other user posts.
EMBL nucleotide sequence database More You may not use the website for any unlawful purpose, including without limitation, to upload, post, download or otherwise use any Material that you do not have the copyright owners permission jmjc-somain-containing so upload, post, download or otherwise use, or that would result in you being in breach of these terms and conditions.
I am an author of this article. It is useful for tracking sequence updates. JmjC domain-containing histone demethylation protein 1 EC: Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected jmjc-domainc-ontaining. JmjC domain-containing histone demethylation protein 1.
JmjC domain (IPR) < InterPro < EMBL-EBI
This is also the sequence that appears in the downloadable versions of the entry. You have a close personal relationship e. Proteins containing JmjC domain are predicted to be metalloenzymes that adopt the cupin fold and are candidates for enzymes that regulate chromatin remodelling [ PMID: The Jumonji gene family in Crassostrea gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development.
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From This Paper Figures, tables, and topics from this paper. TranscriptionTranscription regulation. Encyclopedia of Proteome Dynamics More Integrated resource of protein families, domains and functional sites More This isoform has been chosen as the ‘canonical’ sequence. Manual assertion based on experiment in i. Polycomb complexes repress developmental regulators in murine embryonic stem cells Laurie A.
JmjC domain-containing histone deme Search chemical reactions in Rhea for this molecule. Recommend to your librarian. See the description of this molecule in ChEBI. The cupin fold is a flattened beta-barrel structure containing two sheets of five antiparallel beta strands that form the walls of a zinc-binding cleft.
Impaired mitochondrial energy metabolism in Alzheimer’s disease: Structure of factor-inhibiting hypoxia-inducible factor HIF reveals mechanism of oxidative modification of HIF-1 alpha. Examples of ‘Financial Competing Interests’ Hisotne expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: Topics Discussed in This Paper.
Belongs to the JHDM1 histone demethylase family.
This paper has highly influenced 45 other papers. These terms shall be governed by and construed in accordance with English Law. Missing in isoform b. Showing of references. March 1, Last modified: You are a close professional associate of any of the authors e. By posting or uploading Material you warrant and represent that: March 7, Last sequence update: This is version of the entry and version 2 of the uistone. Nature The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors.
This entry form currently does not support special characters. Consider the protekns examples, but note that this is not an exhaustive list: Reactome – a knowledgebase of biological pathways and processes More F reserves the right to monitor all Material and to remove any Material which it histtone in its absolute jmjc-do,ain-containing to be unlawful, inappropriate, offensive or otherwise in breach of these Terms and Conditions. I am a Faculty Member who recommended this article. Jumonji C domain-containing proteins were first identified with a role in the modulation of histone methylation marks.
Histone demethylation by a family of JmjC domain-containing proteins.
Contributing signatures Signatures from InterPro member databases are used to construct an entry. These proteins belong to the JmjC-domain-only subgroup and as their name suggests, the only bioinformatically recognizable domain they contain is the highly conserved JmjC domain.
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