Glomerulonefrite rapidamente progressiva ANCA-Positiva pauci-imune em paciente com lúpus eritematoso sistêmico. ANCA-Positive pauci-immune crescentic. fawiki گلومرولونفریت سریع پیشرونده; glwiki Glomerulonefrite rapidamente progresiva; itwiki Glomerulonefrite rapidamente progressiva; jawiki 急速進行性糸 . Glomerulonefrite rapidamente progressiva associada a ANCA em uma GN rapidamente progressiva renal associada à ANCA, mesmo com.

Author: Zolorn Ditaur
Country: Morocco
Language: English (Spanish)
Genre: Health and Food
Published (Last): 13 March 2018
Pages: 333
PDF File Size: 2.59 Mb
ePub File Size: 6.48 Mb
ISBN: 373-4-93450-314-6
Downloads: 36403
Price: Free* [*Free Regsitration Required]
Uploader: Faugar

Ten glomeruli had global sclerosis and three had fibro-cellular crescents Figure 2. Riguardo alla forma secondaria della malattia, costituiscono fattore di rischio: Early treatment is a must. As in our patient, clinical and laboratory findings might not always exactly reflect the severity of renal histopathology and thus kidney biopsy is mandatory in such children to guide the clinical management and predict prognosis.

Pauci-immune glomerulonephritis in children: As for the prognostic markers, high serum creatinine on admission was reported to be a poor prognostic factor both for children and adults.

There was no history of arthritis, arthralgia, infection, drug use, or accompanying systemic symptoms. Post-infectious glomerulonephritis PIGN in adults has been associated with a number of pathogens occurring in diverse sites.

The association between Hansen’s and kidney disease has been well documented, with glomerulonephritis GN ranked as the most porgressiva form of renal involvement. Pauci-immune crescentic GN, a renal emergency with acute kidney injury, is relatively rare in children compared to adult patients.

Twenty-three-year review of disease patterns from renal biopsies: Renal ultrasound revealed normal sized kidney and glojerulonefrite thickness with bilaterally increased echogenicity of grade The other glomeruli had mild mesangial proliferation Figure 3 ; findings such as polymorphonuclear infiltration and subepithelial or mesangial deposits humps were not seen.

rapidly progressive glomerulonephritis – Wikidata

The patient described in this case report had glomerulonephritis with complement consumption C3 and biopsy findings suggestive of advanced chronic post-infectious GN with C3 and IgA labeling on immunofluorescence, in addition to fibro-cellular crescents, glomerular sclerosis, and interstitial fibrosis.


She went to an Emergency Unit and was found to have a serum creatinine SCr level of Crescents may form, but are less frequent in cases of pauci-immune GN. Postinfectious glomerulonephritis in the elderly. The patient was started on hemodialysis three times a week. ANCA positivity also commonly accompanies small vessel vasculitis such as granulomatosis with poliangiitis, microscopic poliarteritis nodosa PANand Churg-Strauss syndrome.

March 03, ; Accepted: March 14, ; Accepted: Como citar este artigo. Peripheral blood smear showed normochromic normocytic erythrocyte dominance and no signs of hemolysis. Am J Kidney Dis ; Therefore, she may have had PIGN by Staphylococcusa well-documented manifestation of renal disease in patients with Hansen’s disease.

On physical examination, her weight was 27 kg 50 th percentile and the height cm 50 th percentile. Como citar este artigo.

Tali formazioni visibili attraverso colorazione all’ argento-metenamina prendono il nome di spikes o spinein relazione alla caratteristica forma. Goodpasture syndrome stems from the presence of antibodies targeting the alpha-3 chain of type IV collagen of the GBM, and may manifest as a lung-kidney syndrome marked by linear deposition of IgG on the GBM confirmed by biopsy. Of these 20 crescents, 12 were cellular, 4 fibrocellular, and 4 globally sclerotic.

Clin Exp Nephrol ; J Am Soc Nephrol ;7: Serum protein electrophoresis showed polyclonal increases of alphaglobulin and gamma globulins.

J Am Soc Nephrol ; Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. Electroneuromyography revealed distal mixed axonal demyelinating sensorimotor polyneuropathy with a predominant axonal component and preferential involvement of the right leg, producing severe impairment of the lower limbs and moderate to mild dysfunction of the upper limbs, as seen in cases of infectious neuropathies including Hansen’s diseaseuremia, and vasculitis.


In different pediatric studies, mean age at presentation has been reported to range from 11 to Clinical presentation and outcome of pediatric ANCA-associated glomerulonephritis. In one month, remission was achieved with normal serum creatinine and prednisone was gradually tapered.

It has rapivamente reported that the majority of patients with isolated renal involvement had negative ANCA serology with better clinical outcomes. Immunofluorescence microscopy did not show significant immune deposition.


Renal dysfunction in leprosy: This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Schema di un capillare glomerulare in corso di glomerulonefrite membranosa: Vessels and perivascular areas were normal Figure 1.

Rapidly Progressive Glomerulonephritis

Progfessiva the clinical follow-up, the patient continues in remission. Clin J Am Soc Nephrol ; Here, we report a pediatric case that responded well to initial immunosuppressive treatment despite relatively severe histopathology.

It is more prevalent in males 3: The patient is still on dialysis and is currently weaning from glucocorticoids. The patient described in this case report had RPGN and biopsy findings suggestive of PIGN with C3 and IgA detected on immunofluorescence and kidney injury secondary progressiav recent infection by Staphylococcusa well-documented manifestation of renal impairment in patients with Hansen’s disease.

The patient described in this case report suffered from significant loss of renal function within less than three months and had evidence of glomerular injury, hematuria, and proteinuria, which combined yielded a diagnosis of rapidly progressive glomerulonephritis, later confirmed by its pathological correspondent crescentic glomerulonephritis.

In the following one month, remission was achieved with normal serum creatinine and was 0. Mild to moderate interstitial fibrosis Figure 4acute tubular necrosis, and benign nephrosclerosis were also described. Menu di navigazione Strumenti personali Accesso non effettuato discussioni contributi registrati entra. Antineutrophil cytoplasmic autoantibody-associated progreseiva in children.

Electron-dense subepithelial deposits “humps” may be seen in electron microscopy images if pathology tests are not conclusive after correlation with clinical signs.