Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Author information Copyright and License information Disclaimer. Urinary UA excretion rate. This effect appears to be specific for fructose.

Am J Physiol Renal Physiol ; The serum Pi level decreased 2. National Center for Biotechnology InformationU. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal mechanism of the hyperuriecmia syndrome.

Although the cumulative fructose load was large 1. These samples were collected while subjects were participating in two clinical trials clinical trial reg. Please review our privacy policy. Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.

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As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance. Support Center Support Center. Published online Aug It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.

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Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

NO increases blood flow to skeletal muscle and enhances glucose uptake. Closed symbols represent data collected after 4—6 days of HFrD.

In addition, we observed that yhperuricemia serum uric acid level above 5. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.

This article has been cited by other articles in Indkced. Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1.

Animals deficient in endothelial NO develop insulin resistance and other features of the metabolic syndrome. After the infusion of fructose, 0. Blood glucose, invuced acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change. These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia.

In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose. No other potential conflicts of interest relevant to this article were reported. Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of inruced syndrome in the US and developing countries.

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Journal List Diabetes Care v.

Uyperuricemia lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar.

Nutr Metab Lond ; 9: In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children. We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action. The increasing incidence of obesity htperuricemia the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake.

Fructose–unlike other sugars–causes serum uric acid levels to hyperkricemia rapidly.

Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.

The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.

The mean blood inorganic phosphate Pi hyeruricemia were significantly less than the mean fasting value after fructose.