Tropical sprue (TS) is a syndrome characterized by acute or chronic diarrhea, weight loss, and malabsorption of nutrients. It occurs in residents. Tropical Sprue; Kwashiorkor. Sprue, both tropical and nontropical, has been a subject of great interest to the medical community ever Sp: Esprue tropical. Tropical sprue is a chronic diarrheal disease, possibly of infectious origin, that involves the small intestine and is characterized by.

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Clin Ther 27 — However, immunocompetent people also sometimes show prolonged symptoms. Diseases of the digestive system primarily K20—K93— Rtopical syndrome in India.

These may comprise using only bottled water for drinking, brushing teeth, and washing food, and avoiding tropicao washed with tap water or consuming only peeled fruits, such as bananas and oranges.

The signs of nutritional deficiency include pallor due to anaemia; angular stomatitis, cheilitis and glossitis due to vitamin B deficiency; fsprue peripheral oedema and skin and hair changes secondary to hypoproteinaemia. The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight lossanorexiamalaise, and nutritional deficiencies.

Indian J Med Res 85— Diagnosis of tropical sprue can be complicated because many diseases have similar symptoms. In the meantime, there are things you can try to help calm or quiet your anxiety…. This kills the bacteria overgrowth that results in this condition. It is associated with a macrocytic anemia and megaloblastic bone marrow, and with histological and radiological changes in the small bowel.


The clinician needs to consider various factors when evaluating such patients. Gastroenterology 68 17— Since the introduction of the first birth control pill inwomen have come to rely on the pill as an effective way to prevent pregnancy. Clin Sci Mol Med Suppl 55 — Am J Gastroenterol 95 — Bacterial infections Intestinal tuberculosis is common in tropical countries.

A villous tip accentuation of intraepithelial lymphocytosis was not appreciable in most cases. One possible cause of the syndrome of tropical sprue? Incidence of IPSID is reducing in areas where it was previously prevalent, probably owing to improving hygiene.

Tropical sprue – Wikipedia

Your doctor will trpoical a series of tests to rule out these conditions. These include I belliC parvum and microsporidia. Vitamin B 12 malabsorption may be noted in some people due to lack of pancreatic proteolytic activity and failure to cleave the R protein—vitamin B 12 complex.

Clonal proliferation may occur secondary to chronic or recurrent infections of the intestine in childhood. Am J Trop Med Hyg 10 — This is also called malabsorption.

Tropical malabsorption

The name “sprue” is derived from the Dutch word “sprouw” which means stomatitis. Gut 5 45— Tests for damage caused by malabsorption include:.

Author information Article notes Copyright and License information Disclaimer. Coeliac disease in developing countries: Nutrient malabsorption in tropical sprue arises from involvement of both the proximal and distal small intestine.

Am J Clin Nutr 33 — Middle East, India and North Africa. The mucosa of the small intestine of residents of the tropics is structurally different from that of residents of temperate countries. Assessment of early and delayed responses in vitamin B12 absorption during antibiotic therapy in tropical malabsorption. The list of differential diagnoses in patients with tropical malabsorption is wide and varied.


Night blindness, corneal xerosis, Bitot’s spots. Mucosal biopsy of the small intestine is characteristic and shows troplcal dense cellular lymphoplasmacytic infiltrate in the lamina propria leading to effacement of the crypts. Expert Opin Pharmacother 5 — Patients usually present with profuse diarrhea, weight loss, and malabsorption, notably of tdopical B12 and folate.

In this study, we report the clinical presentation of 12 tropical sprue patients along with the histologic changes of the intestinal mucosa and compare it with those of a series of cases of gluten-sensitive enteropathy, the condition with which it is most frequently misdiagnosed. In this study, 10 of 13 patients with sprue had aerobic bacteria in the small intestine in larger numbers median 3.

Immunoproliferative small intestinal disease: Baker and Klipstein 78 suggested that the diagnosis of tropical sprue should be made only when there is malabsorption of two or more unrelated nutrient groups eg, fat and carbohydrateand after other known causes of malabsorption have been excluded. Semin Gastrointest Dis ; trlpical Clin Microbiol Rev 5 — S Afr Med J 57 — Both beet and cane sugar are found in many foods, including sweets and sodas.

Trop Geogr Med 28 — Digestive disease as a national problem.