Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional. Pittella JE, de Castro LP. Wernicke’s encephalopathy manifested as Korsakoff’s syndrome in a patient with promyelocytic leukemia. South Med. Wernicke encephalopathy (WE) is an acute neurological condition characterized by a clinical Diekfuss JA, De Larwelle J, McFadden SH.

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The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.

Wernicke encephalopathy – Wikipedia

The classical triad is global confusional state, ocular abnormalities and ataxia. To access free multiple choice questions on this topic, click here. An Orphanet summary for this disease is currently under development. Specialised Social Services Eurordis directory. Overweight Obesity Childhood obesity Obesity hypoventilation syndrome Abdominal obesity.

In his two years study, Francini-Pesenti observed a high prevalence of WE in this type of patients, 3 a conclusion similar to that of Hahn, that reported an increase of this syndrome in patients with TPN, that due to a shortage of multivitamin infusions, were not receiving thiamine.

The classic triad of symptoms found in Wernicke encephalopathy is: In a series of autopsy studies held in Recife, Brazil, it was found that only 7 out of 36 had had alcoholic habits, and only a small minority had malnutrition.

The observation of edema in MR, and also the finding of inflation and macrophages in necropsied tissues, [49] has led to successful administration of antiinflammatories. Dementia due to thiamine deficiency Prevalence: A case associated with a liquid-only diet.

[Wernicke’s encephalopathy and Caine criteria. Report of six cases].

Some other warning signs could include hyperthermia and hypotension. Oedema may be found in the regions surrounding the third ventricleand fourth encefalopxtiaalso appearing petechiae and small hemorrhages. Treatment with mg intravenous thiamine, three times per day, was started, with remission of the nystagmus and significant improvement of his confusional state in the three following days.


Since many WE patients are managed as outpatients, the pharmacist should encourage abstinence from alcohol. Clinical manifestations were drowsiness, psychomotor hyperactivity, ophthalmoplegia with bilateral abduction impairment, horizontal nystagmus; three patients with ataxia and appendicular dysmetria.

Etiology Thiamine deficiency is characteristically associated with severe alcohol use disorder. When it occurs simultaneously with alcoholic Korsakoff syndrome it is known as Wernicke—Korsakoff syndrome. StatPearls Publishing ; Jan. Wernicke’s lesions were observed in 0.

The role of the nurse, dietitian, social worker, and pharmacist cannot be overemphasized.

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Since the cornerstone of therapy is thiamine, the importance of compliance is vital.

Classically, Wernicke encephalopathy is characterised by the triad — ophthalmoplegiaataxiaand confusion. A dietary consult should be done to assess the calorie needs and determine how to provide the food as well as thiamine. Following this an immediate intravenous or intramuscular dose of thiamine should be administered [32] two or three times daily. During his stay, the patient presented a new episode of upper digestive hemorrhage requiring surgical intervention, in which a partial gastrectomy and Roux-en-Y Gastric Bypass was made.

Brain and Nerve in Japanese. There are no conclusive statistical studies, all figures are based on partial studies, and because of the ethical problems in conducting controlled trials are unlikely to be obtained in the future. Thiamine, also called B1, helps to break down glucose. There are hospital protocols for prevention, supplementing with thiamine in the presence of: This book is distributed under the terms of the Creative Commons Attribution 4. Color Atlas of Neurology.


Thiamine is first metabolised to its more active form, thiamine diphosphate TDPbefore it is used.

Encefalopatía de Wernicke asociada a nutrición parenteral total

After withdrawing the sedatives and extubating the patient, a confusional state with important mental sluggish was noticed, accompanied also by horizontal nystagmus to both sides and paralysis of the left arm. Review [Wernicke encephalopathy and Korsakoff’s psychosis: Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient. Health care resources for this disease Expert centres 0 Diagnostic tests 0 Patient organisations 0 Orphan drug s 0.

Sequeira Lopes da Silva 1R. Thiamine is a water-soluble B-complex vitamin that participates as a coenzyme in the oxidative decarboxylation of pyruvate and alfa-ketoglutarate and also in the pentose phosphate pathway. Wernicke encephalopathy WEalso Wernicke’s encephalopathy [1] is the presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine vitamin B1.

Most symptoms will improve quickly if deficiencies are treated early. Wernicke’s syndrome during parenteral feeding: As a much more diverse range of symptoms has been found frequently in patients it is necessary to search for new diagnostic criteria, however Wernicke encephalopathy remains a clinically-diagnosed condition.

Despite the fact that Wernicke’s encephalopathy, in developed wetnicke, is frequently associated with chronic alcoholism, there have been a number of published cases associating this encephalopathy with parenteral feeding without vitamin supplementation.

Support Center Support Center. PMC ] [ PubMed: Wernicke’s encephalopathy is an acute neurological syndrome due to thiamine deficiency, which is characterized by a typical triad of mental status changes, oculomotor dysfunction and ataxia.