Citicoline is a medicine available in a number of countries worldwide. A list of US medications equivalent to Citicoline is available on the website. Choline C 11 Injection, for intravenous use. Initial U.S. Approval: INDICATIONS AND USAGE Choline C The Federal Food, Drug, and Cosmetic Act requires that manufacturers and distributors who wish to market dietary supplements that contain.

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The Complete Drug Reference [ed. Citicoline In the US, Citicoline is a member of the drug class oral nutritional supplements. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea. Close regulation of its biosynthesis, degradation, and distribution is essential to proper cell function. The brain preferentially uses choline to synthesize acetylcholine.

The Journal of Biological Chemistry. To view content sources and attributions, please refer to our editorial policy. Methods and Findings in Experimental and Clinical Pharmacology.


Citicoline is available as a supplement online and in stores. This means it is still under development and may contain inaccuracies. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Retrieved from ” https: By clicking Subscribe, I agree to the Drugs.

Consult with your healthcare professional before taking any medication. Studies suggest that CDP-choline supplements increase dopamine receptor densities. Available for Android and iOS devices.

Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. Citicoline dfa a very low toxicity profile in animals and humans. Citicoline also increases glutamate uptake by increasing expression of EAAT2a glutamate transporterin vitro in rat astrocytes.


Journal of Neuroscience Research.

Further information on drug naming conventions: London UK ; e-version. This can lower levels of hydroxyl radicals produced citioline an ischemia and prevent cardiolipin from being catabolized by phospholipase A2. Citicoline INNalso known as cytidine diphosphate-choline CDP-Choline or cytidine 5′-diphosphocholine is an intermediate in the generation of phosphatidylcholine from cholinea common biochemical process in cell membranes.

Int J Mol Sci. British Journal of Pharmacology.

Citicoline enhances cellular communication by increasing the availability of neurotransmitters, including acetylcholinenorepinephrineand dopamine. Nicotinic acetylcholine receptor modulators. A review of published clinical trials of citicoline noted that while some studies have demonstrated positive effects of the compound on cognition, other studies have failed to confirm these results and additional clinical trials would be needed to confirm any potential benefits of citicoline.

These phospholipids include sphingomyelin and phosphatidylcholine. It is sold in over 70 countries under a variety of brand names: Phosphatidylcholine is synthesized in vivo by two pathways.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal fsa. Cytidine 5′- trihydrogen diphosphatemono[2- trimetylammonio etyl] ester, hydroxide, inner salt. The effect of citicoline on visual function has been studied in patients with glaucoma.

When the availability of choline is low or the need for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other diticoline professional.

Views Read Edit View history. This limits the amount of choline available to synthesize phosphatidylcholine. Reviews in Neurological Diseases. Subscribe to free Drugs. By using this site, you agree to the Terms of Use and Privacy Policy. The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelinpreservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolaminepartial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.


Despite some suggestions that citicoline may reduce the rates of death and disability following an ischemic stroke[10] [11] the largest citicoline clinical trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling patients, found no benefit of administering citicoline on survival or recovery from stroke. Subscribe to receive email notifications whenever new articles are published.

Cholinergics Nootropics Nucleotides Quaternary ammonium compounds Choline esters. Fdw the US, Citicoline is a member of the drug class oral nutritional supplements. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Citicoline wins EU novel foods approval – in medical foods and food supplements

Retinol Vitamin A B vitamins: From Wikipedia, the free encyclopedia. Citicoline lowers increased glutamate concentrations and raises decreased ATP concentrations induced by ischemia. We comply with the HONcode standard for trustworthy health information – verify here.

This page was last edited on 14 Septemberat Muscarinic acetylcholine receptor modulators.