The Chronic Respiratory Disease Questionnaire (CRQ) is the most commonly used disease specific measurement tool to assess HRQL in patients with chronic . Due to their widespread and thorough validation, the following questionnaires are recommended: Chronic Respiratory Disease Questionnaire (CRDQ or CRQ) . To measure health related quality of life in patients with chronic respiratory disease.

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Important considerations for questionnaires such as CRQ include the ease and cost of administration.

The instrument consists of 20 questions scored on a 7-point Likert-type scale in four domains: A measure of quality of life for clinical trials in chronic lung disease. Reliability and validity of the chronic respiratory questionnaire CRQ Thorax. It is recommended that both general and condition specific HRQL questionnaires be administered alongside physiologic tests since each of these contribute unique information regarding disease state and quality of life.

The evidence has shown that the CRQ is a valid tool to assess health related quality of life in patients with chronic respiratory disease.

Again, considerable improvements in the questionnairf were seen in all domains of the original version. Foundations of Clinical Research: Because responsiveness might be of highest priority for some users of the CRQ, a version was developed that is self-administered but includes individualized dyspnea questions.

Physiologic factors that determine the health-related chonic of life in patients with COPD. A mean change per question of 0. Lower correlation chroinc were noted in the second 6 month period; cyronic, they were not significant enough to indicate that bias existed between assessments. This property can also aid researchers when gathering resources to conduct studies by enabling them to calculate appropriate sample sizes.

Many studies reported internal consistency of the questionnaire to be high over all domains 391319 with Cronbach’s alpha coefficients ranging from 0. When less responsive tools are used, it is likely that the treatment effects can be underestimated. A novel, short, and simple questionnaire to measure health-related quality of life in patients with chronic obstructive pulmonary disease. Each domain includes 4 to 7 items, with each item graded on 7-point Likert scale; chronix scores within a domain are summated to provide a total score for each domain.

The researchers found that according to the patient, a point decrease in a specific domain score of the CRQ reflected small respiratogy in HRQL, and that according to both patients and PCPs, a point increase on the domain scores of the CRQ reflected a small, but clinically important improvement in HRQL. Using 2 rounds of the Delphi method, one in person meeting and a repetitive enhancement process for circulating and correcting the final report, they were able to determine the values of change for each domain that would result in a small, moderate, and large MCID.


Other useful means of the measure are interpreting studies that show significant findings and improvement of expressing results.

Chronic Respiratory Questionnaire (CRQ) | Flintbox

One hundred twelve patients participated in the study. There is currently no gold standard for determining HRQL, 20 so the validity of the CRQ has questionnaite assessed primarily through construct and convergent validity.

The CRQ are validated and reliable quality of life measures for patients with chronic respiratoru limitations. According to the office of the developer written communication, October, there are currently 4 different formats of the CRQ available for clinical use: The CRQ is available in four different formats approximate time needed for the first administration: Available applications through flintbox: They administered the questionnaire 6 times in a 2-week interval to 25 patients with stable COPD.

Pearson correlation coefficients were used to determine consistency over time of both individual item scores and domain total scores. High response rates to this type of questionnaire have been achieved in outpatient settings; however, the interview form is quite expensive questiohnaire and time consuming.

The expert panel recommended that Chornic be associated with a change greater than 2 points in the domain score.

Chronic Respiratory Disease Questionnaire-CRQ

Fatigue domain scores also improved as shuttle walk test scores improved. The advantage of this version is that there is no requirement for presence of an interviewer during the completion of the questionnaire.

In order for a test to be useful in the clinic, the instrument must be consistent in its measurements. Wijkstra et al 10 found that the internal consistency of the dyspnea domain to be much lower than the other 3.

Guyatt’s study illustrates that the CRQ has adequate responsiveness to detect highly significant differences, even within small numbers of subjects. Prentice Hall Health; The conventional method of determining the MCID relies on the patient’s report as to the degree of change they have experienced in comparison to themselves; questiinnaire, the method by Redelmeier et al 24 requires the patient to report the status of their condition in comparison to other patients with the same condition.


It has been used extensively in research and clinical trials since Because under some circumstances investigators will want to use identical questions for ALL respondents the CRQ has chronlc standardized through inclusion of five identical questions inquiring about dyspnea. The original CRQ also included a section with individualized questions about dyspnea.

Also available is the self-administered version of the CRQ. Author information Copyright and License information Disclaimer. ICCs of short term reliability ranged from 0. It has high internal consistency and test-retest reliability, as well as moderate to strong construct and convergent validity.

The developers found that the CRQ scores at the follow-up assessment were, to a large extent, better than at the initial distribution of the questionnaire, even though respriatory values were only slightly improved.

Chronic Respiratory Disease Questionnaire-CRQ

When all 4 of the domains were included, the MCID was 0. Harper et al 13 also examined CRQ measurements in clinically stable patients over time. A methodological framework for assessing health questionnairs.

The fact respirstory correlations with physiologic measures are not strong suggests that HRQL instruments such as the CRQ may provide additional information that should be used alongside physiologic tests in determining the health status of a patient.

Measuring patient and clinical perspectives to evaluate change chronoc health-related quality of life among patients with chronic obstructive pulmonary disease. The CRQ requires a licensing agreement as well as a significant time commitment for administration. Please review our privacy policy. With the development of the self-administered CRQ, validity of the newer instrument was established by comparing it to the gold standard of the original version.

Clinically important changes in health-related quality of life for patients with chronic obstructive pulmonary disease: Guyatt et al 2 the authors of the CRQ, established the test-retest reliability of the tool prior to its release.

The CRQ was developed to assess quality of life in patients with chronic respiratory disease, including COPD of longer than qjestionnaire months and other disease processes that lead to chronic airflow limitations.