drug-related adverse reaction leading to caspofungin discontinuation was The printed package leaflet of the medicinal product must state the name and. CANCIDAS® is a sterile, lyophilised product for intravenous infusion that contains a Interpretive standards (or breakpoints) for caspofungin against Candida. CANCIDAS* is a sterile, lyophilized product for intravenous (IV) infusion that CANCIDAS is the first of a new class of antifungal drugs (glucan synthesis.
|Published (Last):||18 October 2018|
|PDF File Size:||3.23 Mb|
|ePub File Size:||6.8 Mb|
|Price:||Free* [*Free Regsitration Required]|
Administering inducers of hepatic cytochrome P, such as efavirenz, concurrently with caspofungin may reduce the plasma concentrations of caspofungin. Treat for several weeks, followed by oral fluconazole for patients who are unlikely to have a fluconazole-resistant isolate.
Isnert adjustment information is only available for adults. In cases where pneumonia is associated with disseminated infection, 70 mg IV loading dose on day 1, then 50 mg IV once daily.
Caspofungin Acetate for Injection Now Available from Fresenius Kabi
There have been no well-controlled studies in pregnant women. Please see the full prescribing information for Caspofungin Acetate for Injection, including boxed warning, cancidad http: Fresenius Kabi is a global health care company that specializes in medicines and technologies for infusion, transfusion and clinical nutrition.
Caspofungin has not been studied for safety and efficacy in infants less than 3 months of age, including neonates. Your email has been sent. The Important Safety Information does not include all the information needed to use Caspofungin Acetate for Injection safely and effectively.
In general, the safety profile of caspofungin insegt pediatric patients is comparable to that of adult patients. Related Drug Information Drug Summary. Studies to evaluate the effects of exposure on a breast-fed infant have not been conducted; however, based on caspofungin’s poor oral absorption, the risks appear to be low.
Reference s National Institutes of Health, U. Moderate Use dichlorphenamide and caspofungin together with caution. Microbiology Mechanism of Action Caspofungin acetate, canicdas echinocandin, is an antifungal agent.
Caspofungin acetate (Cancidas ®) – GlobalRPH
The clinical significance of the extensive tissue accumulation is unknown, but may contribute to lnsert activity of the drug against localized tissue infections.
Do not store for inesrt use. A single mg loading dose should be administered on Day 1, followed by 50 mg daily thereafter. Treat suppurative thrombophlebitis for at least 2 weeks after candidemia if present has cleared. Surgical debridement may be helpful in some cases of osteomyelitis and is recommended for all cases of septic arthritis.
The manufacturer recommends against the concomitant use of caspofungin with cyclosporine unless the potential benefit outweighs the risk.
For the treatment of Aspergillus pneumonia and pleural space infections in patients who are refractory to or intolerant of other antifungal therapies.
Although an increase in efficacy with 70 mg daily has not been demonstrated, limited safety data suggest that an increase in dose to 70 mg daily is well tolerated.
Recommended as an alternative to fluconazole as initial therapy. Administering inducers of hepatic cytochrome P, such as ethotoin, concurrently with caspofungin may reduce the plasma concentrations of caspofungin.
For the treatment of Aspergillus cardiovascular system infections in patients who are refractory to or intolerant of other antifungal therapies.
Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. The pathway of chemical degradation is uncertain. Animal studies reveal distribution primarily into the liver and kidneys. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions. Canciads and administration 2.
For neonatal candidiasis, amphotericin B or fluconazole is the preferred therapy. Chemical degradation leads to the formation of the metabolite L and very low levels of reactive intermediates.
Cyclosporine concentrations are not altered by coadministration with caspofungin. The final diluted infusion may be stored for up to 24 hours at 25 degrees C or less 77 degrees F lnsert lessor for up cxncidas 48 hours under refrigeration at 2 to 8 degrees C. Very limited data are available. No adjustment needed in mild impairment.
Duration of treatment should be individualized to the indication, as described for each indication in adults [see Dosage and Administration 2. These mutations are associated with higher MICs and breakthrough infection.