Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.
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The hyperglycemic effect of diazoxide is expected to be antagonized by certain antidiabetic agents e. Moderate Sulfonamides may enhance the hypoglycemic action of antidiabetic agents; patients with diabetes mellitus should be closely monitored during sulfonamide treatment. Moderate Disopyramide may enhance the hypoglycemic effects of antidiabetic agents. The mechanism of this interaction is not available although it may be due to delayed gastric emptying from exenatide use and the clinical impact has not been assessed.
Exenatide acutely improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes. Following a single subcutaneous injection, exenatide is released from the suspension microspheres over approximately 10 weeks.
When possible it may be prudent to take any oral medication at least 1 hour prior to administration of injectable exenatide, although specific research addressing this issue is not available. Therefore, the use of exenatide is not recommended in patients with severe GI disease e.
Type 2 Diabetes Medication | BYETTA® (exenatide) injection
Your Name Your name is required. In patients with byyetta 2 diabetes, exenatide moderates glucagon secretion and lowers serum glucagon concentrations during periods of hyperglycemia. Exenatide is not a substitute for insulin in patients who require insulin. If pancreatitis is suspected, BYETTA should be discontinued promptly and should not be restarted if pancreatitis is confirmed.
Subcutaneous dosage extended-release once weekly injection suspension, Bydureon or Bydureon BCise. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis.
Temporary use of insulin in place of oral antidiabetic agents may be necessary during periods of physiologic stress e. Moderate Tacrolimus has been reported to cause hyperglycemia. Dosage adjustments of warfarin may be necessary. Inject subcutaneously into the thigh, abdomen, or upper arm.
Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay byetta recovery of blood glucose to normal levels. More controlled trials are needed to discern if garlic has an effect on blood glucose pacage patients with diabetes.
The hypoglycemia or hyperglycemia which occurs during octreotide acetate therapy padkage usually mild, but may result in overt diabetes mellitus or necessitate dose changes in insulin or other hypoglycemic agents. While still holding the pavkage upright, unscrew the orange cap. A selective beta-blocker may be preferred in patients with diabetes mellitus, if appropriate for the patient’s condition.
Exenatide AUC increased proportionally over the therapeutic dose range of 5 to 10 mcg. Moderate Salicylates, by inhibiting prostaglandin E2 synthesis, can indirectly increase insulin secretion.
Blood glucose concentrations should be closely monitored if lithium is taken by the patient. After that, patients can resume their usual dosing schedule of once every 7 days weekly. Exenatide mimics the enhancement of glucose-dependent insulin secretion and other antihyperglycemic actions of incretins. Exenatide is given via subcutaneous administration.
Your risk for getting low blood sugar hypoglycemia is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin.
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Extended-release exenatide is not a first-line therapy for patients inadequately controlled on diet and exercise. The effect of exenatide to slow gastric emptying may reduce the extent and rate of absorption of orally administered drugs.
Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol or equivalent per day in combined oral contraceptives COCswhich are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. This interference can lead to a loss of diabetic control, so diabetic patients should be monitored closely if these drugs are initiated. Linezolid is a reversible, nonselective MAO inhibitor and other MAO inhibitors have been associated with hypoglycemic episodes in diabetic patients receiving insulin or oral hypoglycemic agents.
Medicine is mixed well when it appears as an even mix that is cloudy.
Medicine is mixed well when it appears as an even mix that is cloudy; it is okay to see air bubbles. Although specific dose recommendations are not available, a lower dose of the insulin may be required to reduce the risk of hypoglycemia in this setting. Exenatide does not impair the normal glucagon response to hypoglycemia. The manufacturer of exenatide provides an insulin glargine dose titration algorithm to aide clinicians when using exenatide with insulin glargine; consult product labels.
The most frequently reported adverse reactions leading to withdrawal for Byetta-treated patients were nausea 5.
Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: Patients on antidiabetic agents should be monitored for the need for dosage adjustments during the use of pentamidine.
Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. In severe hypoglycemia, intravenous dextrose or glucagon injections may be needed. If a patient with diabetes ingests alcohol, they should be counselled to to avoid ingestion of alcohol on an empty stomach, which increases risk for low blood sugar. Combined use with prandial insulin has not been studied and cannot be recommended.
Tobacco smoking is known to aggravate insulin resistance. Go to Healthcare Professional Site.
Staying Active Learn how regular physical activity can help you packqge type 2 diabetes. Recommendations will be communicated once the review is complete; continue to consider precautions related to pancreatic risk until more data are available.
After acute overdose, aspirin can cause either hypo- or hyperglycemia. Altered renal function was reversible in many cases with supportive treatment and discontinuation of potentially causative agents, including exenatide. After first use, the Byetta Pen injector can be kept at a temperature not to exceed 77 degrees F 25 degrees C.