PI & CMI Trade Names and Active Ingredients containing insulin glulisine. 1 Documents available. Need more information on a Apidra, CMIPI, Insulin glulisine. PI & CMI Trade Names and Active Ingredients containing insulin. 42 Documents Actrapid, PI, Insulin – human (human insulin) Apidra, CMIPI, Insulin glulisine. Apidra PI MKT. #v Page 1. PRODUCT INFORMATION. APIDRA APIDRA [insulin glulisine injection {rDNA origin}] is a recombinant human insulin .

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Do not shake the vial. Table 4 Ongoing phase 4 studies of glulisine in children and adolescents.

The role of insulin glulisine to improve glycemic control in children with diabetes mellitus

The main outcome data in the efficacy studies were changes in HbA 1c at study completion. When glulisine oi compared with RHI in a small crossover trial in 10 adolescents and 10 children with type 1 diabetes, no safety concerns arose. Pre-filled pens that are first carried as a spare for a while must also be discarded 28 days after being removed from the refrigerator.

Symptoms of severe hyperglycaemia include:. Type 1 diabetes mellitus is one of the most common chronic diseases in children in the developed world.

Efficacy and safety of insulin glulisne in japanese patients with type 1 diabetes mellitus; using glargine as basal insulin [Abstract Number PO] Diabetes.

Comparative studies with the other rapid-acting insulin analogs are needed before the place of glulisine in the management of children and adolescents with type 1 diabetes can be better defined. Certain heart medications, especially beta-blockers, may mask the symptoms of hypoglycaemia.

Your dose of Apidra or other medicines may need to be changed. Before first use, store the pre-filled pen at room temperature apidrz 1 to 2 hours. Your doctor may increase or decrease the dose, apidar on your blood sugar levels. Illness, especially with nausea and vomiting, may cause your insulin needs to change. Mixing Apidra with NPH isophane insulin. Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose.

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The potential to give glulisine immediately after a meal, once food intake is known, can be invaluable in young children in whom carbohydrate and other food intake can vary widely and be difficult to predict. Click here pu information on Sharps Medical Waste Disposal.

Fluid retention and heart failure can occur with concomitant use of thiazolidinediones TZDs with insulin. Enquiries were made to sanofi-aventis on future research, there are two ongoing Phase IV clinical trials currently in progress, the results of which are yet to be published.

Do not re-use empty cartridges. If you do not respond to glucagon treatment, you will have to be treated in a hospital. Targets and Therapy are provided here courtesy of Dove Press. Your doctor and pharmacist apisra a full list of medicines with which you must be careful or avoid while using Apidra.

Prepubertal tanner stage I Type 1 diabetes mellitus with positive islet cell antibodies or presenting at time of diagnosis with positive serum or urine ketones and requiring insulin since diagnosis HbA 1c 6. Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs. Insert the needle into the skin as recommended by your healthcare professional. Severe hyperglycaemia can lead to unconsciousness and, in extreme cases, death if untreated.

If the product appears cloudy, discoloured or contains particles, or if the injection pen, cartridge or vial appears damaged. Put the needle through the rubber top of the NPH insulin vial and inject air into the vial. Tell your doctor if you are exercising more than usual. Once all the insulin is used, you cannot replace the cartridge. There is a theoretical concern that they could increase the risk of tumor development due to altered binding characteristics to insulin and insulin-like growth factor IGF -1 receptors caused by the structural changes made to the native insulin molecule.

Taking other medicines Tell your doctor if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

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The role of insulin glulisine to improve glycemic control in children with diabetes mellitus

Tell your doctor if your diet changes. It does not take the place of talking aapidra your doctor, apifra or diabetes educator. Health-related quality-of-life results from multinational clinical trials of insulin lispro: You and your doctor should design an insulin plan for those times when you are sick. Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes.

An injection of the hormone glucagon may speed up recovery from unconsciousness. Make sure you are using the correct injection pen, cartridge or vial.

Using one insulin type Apidra. Articles from Diabetes, Metabolic Syndrome and Obesity: Tell your doctor if you notice anything that is making you feel unwell. Assessing benefits of a new diabetes therapy. Garg S, Kelly WC. Only mix Apidra with another insulin if your doctor has instructed apira to do so.

Do not reuse needles. Glulisine versus aspart There were no trials comparing the efficacy of glulisine pk aspart in pediatric patients. Apidra is a short-acting insulin.

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A double-blind, randomized, crossover study of 20 pediatric patients incorporated a single-dose 0. The baseline characteristics of these adult type 1 diabetes participants were similar between the two groups glulisine vs lispro. Exp Clin Endocrinol Diabetes. Dispose of your insulin syringes safely into a sharps container. Sanofi US reserves the right to rescind, revoke, or amend the program without notice. A week, multicenter, centrally randomized noninferiority trial compared the efficacy of glulisine with lispro in children aged 4 to 17 years with type 1 diabetes treated with basal insulin either glargine once daily or NPH twice daily.

If glucagon is used, have some sugary food or drink as soon as you are conscious again.