Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.

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Journal of Clinical Pathology 6: British Phycological Journal Halimeda discoidea Chlorophyta con actividad semejante a la heparina. Caulerpa paspaloides Chlorophyta was active only in the thrombin time test. Purification and characterization of two fibrinolytic enzymes from the marine green alga, Codium intricatum. SPB Academic Publishing bv. American Journal of Human Genetics 48 5: We also detected a variation in the anticoagulant potency, a change in the anticoagulant activity related with the intrinsic or extrinsic pathways of coagulation or even the disappearance of the anticoagulant activity in both test of Caulerpa cupressoidesC.

The discovery of alternative anticoagulant molecules must be an important task for scientists. Annals coagulacionn Internal Medicine Bases de datos de enzimas. Se concluye que estas especies pueden ser consideradas como una fuente alternativa de nuevos anticoagulantes.

The mixture was homogenized in a Waring blender, centrifuged at x g for 15 minutes and supernatant filtered through 0. Cada cadena posee una masa molecular de aproximadamente 80 British Journal of Haematology 90 4: Anticoagulant, fibrinolytic and antiaggregant activity of carrageenans and alginic acid.


Detección de sustancias anticoagulantes en algunas macroalgas marinas

Consultado el 7 de abril de We can concluded that these species can be considered as potentially alternative source of anticoagulant molecules. A delay in clot formation less than two minutes was observed in prothrombin time test intriseca this species from Chlorophyta: Screening for anticoagulant substances in some marine macroalgae.

It has been done research in anticoagulant activity of polysaccharides and glycosaminoglycans of diverse sources such as: It has been reported also that brown algae have a potent anticoagulant activity in fucoidans Chevolot et al. Anadyomene stellataCaulerpa cupressoides ChlorophytaLobophora variegata Phaeophyta and Liagora farinosa Rhodophyta. Thrombosis and Haemostasis 86 1: Occurrence of heparin in the invertebrate Styela plicata Tunicata is restricted to cell layers facing the outside environment.

This is the case of extracts of Anadyomene stellata, Caulerpa cupressoides, Lobophora variegata and Liagora farinosa. Standardized plasma coagulation tests thrombin and prothrombin time were used. Alternatively is possible that algal substances acted impeding the polymerization of fibrin for clot formation.

Biochimica et Biophysica Acta Antimicrobial and cytotoxic terpenoids from tropical green algae of the family Udoteaceae. Epiphytes were removed carefully from the algae extirnseca the microscope to avoid contamination. An anticoagulant proteoglycan from the marine green alga, Codium pugni-formis. Anticoagulant activity in extracts of British marine algae.

Factor de coagulación XI

The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Mexican Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2. El factor IXa, por otro lado, activa al factor X. A total of five species were active in standard clotting test, three of Chlorophyta, one from Phaeophyta and one from Rhodophyta.


The New England Journal of Medicine 3: An International Journal in Haemostasis and Thrombosis 16 4: Current views on blood coagulation and haemostatic mechanism.

We can concluded that some substances present in the algal extract can act on any of the enzyme or cascasa inhibiting the transformation of prothrombin to thrombin or in the activation process of fibrinogen to fibrin. Anticoagulant and antithrombin activities of oversulfated fucans.

Recently, a group of scientists had stand out the potentiality of some proteins and proteoglycans capable of interfere with blood clotting cascade, particularly from Codium Matsubara et al. The extracts could act preventing the conversion of prothrombin to thrombin, also they could act stopping the transformation of fibrinogen to convert it to fibrin o even in the polymerization of this last molecule.

Niveles elevados de factor XI han sido implicados en casos de trombosisaunque es incierto que es lo que determina estos niveles, y cuan severo puede ser el estado procoagulante. The extract of L. Journal of Molecular Biology 2: Other seven species presented a slightly anticoagulant activity.

The Hague, The Netherlands.